The Mitchell lab is recruiting. Positions for researchers at various career stages are now available as well as places for undergrad interns. Please visit the Join section to read more.
Amir Mitchell, PI. (CV)
I'm an assistant professor in the Program of Systems Biology at the University of Massachusetts Medical School. I started my career in the interdisciplinary program at Tel-Aviv university majoring in Biology and Computer Science. Moving to the Weizmann Institute of Science I did my PhD at Yitzhak Pilpel's lab exploring how microorganisms can evolve to anticipate sequential changes in their environment analogous to classical Pavlovian Conditioning. Fascinated with the synergistic potential of combining experimental and theoretical approaches I moved to Wendell Lim's lab at UCSF for my postdoctoral studies. My research there focused on failure point in cell regulatory networks and uncovered resonance-like phenomenon in cell response. Currently I am studying how diverse cell types respond and adapt to dynamic temporal inputs in an attempt to uncover novel Achilles' heels in cell behavior.
Fang Xie, Postdoc
I completed my PhD studies in Genetics at Fudan University under Dr. Long Yu’s supervision to identify novel small molecule inhibitors targeting Aurora kinases. I then worked with Drs. Liewei Wang and Richard Weinshilboum as a postdoctoral fellow at Mayo Clinic, my research was focused on pharmacogenomics of endocrine therapy for breast cancer and translational medicine models for prostate cancer. Being fascinated with the great potential of System Biology in cancer research, I joined Mitchell lab. My research focuses on decoding the behavior of cancer cells and uncovering the underlying mechanisms of drug resistance in cancers. Working with Dr. Amir Mitchell, I am exploring dynamic dosing strategies to intervene refractory cancers and interrogating cellular heterogeneity in these cancers at the single-cell level.
Payam KhoshkenaR, Research Associate
I received my B.Sc. in Biomaterial Science from Tehran Polytechnic and my M.Sc. of Biomedical Engineering from Louisiana Tech University. I worked on construction of electrochemical biosensors as my senior undergraduate project and polymeric/liposomal nanoparticles for drug delivery applications in my masters degree. After my masters, I moved to Koch Cancer Institute at MIT as formulation scientist and worked on synthesis of a chemotherapeutic oral film. My next position was a Research Associate in the Program in Molecular Medicine at UMass Medical School where I worked on synthesis and characterization of subunit vaccines based on Glucan Particle technology. I moved to the Mitchell lab to study the cell-cell variability in anticancer therapy while focusing on the dynamics of signaling networks in clonal cell populations.
Nicholas Vecchietti, Research Associate
I received both my B.Sc. and M.Sc. in Biology at the University of Insubria in Varese, Italy. My thesis project was conducted in Switzerland in collaboration with the Laboratory of Applied Microbiology lead by Dr. Mauro Tonolla at SUPSI University, where I investigated the eco-physiological interaction between anaerobic sulfur bacterial species. During that time, I gained experience in microbiology, microscopy and image analysis techniques. After my graduation, I joined UMass as Research Associate where I was optimizing techniques allowing live imaging of HIV-1 virus and collaborating in assembling a state of the art microscope for tracking viral particles during infection in cells. Currently in Mitchell’s lab I am investigating the response of yeast cells to stress conditions and I am participating in the studies on the evolution of antibiotic resistance in E.coli applying my expertise in microbiology and microscopy techniques.
Serkan Sayin, PhD student
I have received my B.Sc. in Molecular Biology and Genetics from the Izmir Institute of Technology where I performed research at Professor Ahmet Koc’s lab which studies aging and drug resistance using S. cerevisiae. I moved to Germany to pursue my M.Sc. degree in Life and Medical Sciences at the University of Bonn at the group of Prof. Dr. Joachim Schultze and Dr. Marc Beyer. Their research uses genomics approaches to solve complex immunology problems in macrophage and T-cell biology. There, I focused on genome engineering of macrophages by CRISPR/Cas9 to study long range DNA interactions. Currently, I am a graduate student at the University of Massachusetts Medical School. I have a diverse background in different fields of biological sciences, and now I would like to challenge myself in an interdisciplinary area of Systems Biology. I have recently joined the Mitchell lab to work on evolution of antibiotic resistance in E.coli and plasmid partitioning.
Andrea Karduss, VISITNG STUDENT
I'm originally from Venezuela and I came to the US to study Biomedical Engineering and Tissue Engineering at the Worcester Polytechnic Institute. I am also minoring in Global Public Health since my passion is to drive worldwide healthcare progress throughout my career path. I am currently working with Shaimae Elhajjajy on my Major Qualifying Project at the Mitchell Lab. We are building a programmable and automated microfluidics system. This system aims to simulate in a more accurate way the in-vivo environment of cells within an organism. After building the system we intend to study the cell response to the environmental changes and help the team monitor dynamics of cell behavior.
Shaimae Elhajjajy, VISITING STUDENT
I am currently an undergraduate student at Worcester Polytechnic Institute (WPI) studying Biomedical Engineering with a concentration in Biomaterials/Tissue Engineering. I am also planning to complete two minors in Computer Science and Bioinformatics/Computational Biology. Along with my partner Andrea, I am completing my senior year Major Qualifying Project in the Mitchell Lab. We will be working to design and construct a programmable multi-pump system for cell culture experiments. We will also perform some experimental work using this engineered platform to examine the cellular response to dynamic doses of anti-cancer drugs.