The Mitchell lab is recruiting. Positions for researchers at various career stages are now available as well as places for undergrad interns. Please visit the Join section to read more.
Amir Mitchell, PI. (CV)
I'm an assistant professor in the Program of Systems Biology at the University of Massachusetts Medical School. I started my career in the interdisciplinary program at Tel-Aviv university majoring in Biology and Computer Science. Moving to the Weizmann Institute of Science I did my PhD at Yitzhak Pilpel's lab exploring how microorganisms can evolve to anticipate sequential changes in their environment analogous to classical Pavlovian Conditioning. Fascinated with the synergistic potential of combining experimental and theoretical approaches I moved to Wendell Lim's lab at UCSF for my postdoctoral studies. My research there focused on failure point in cell regulatory networks and uncovered resonance-like phenomenon in cell response. Currently I am studying how diverse cell types respond and adapt to dynamic temporal inputs in an attempt to uncover novel Achilles' heels in cell behavior.
Fang Xie, Postdoc
I completed my PhD studies in Genetics at Fudan University under Dr. Long Yu’s supervision to identify novel small molecule inhibitors targeting Aurora kinases. I then worked with Drs. Liewei Wang and Richard Weinshilboum as a postdoctoral fellow at Mayo Clinic, my research was focused on pharmacogenomics of endocrine therapy for breast cancer and translational medicine models for prostate cancer. Being fascinated with the great potential of System Biology in cancer research, I joined Mitchell lab. My research focuses on decoding the behavior of cancer cells and uncovering the underlying mechanisms of drug resistance in cancers. Working with Dr. Amir Mitchell, I am exploring dynamic dosing strategies to intervene refractory cancers and interrogating cellular heterogeneity in these cancers at the single-cell level.
Payam KhoshkenaR, Research Associate
I received my B.Sc. in Biomaterial Science from Tehran Polytechnic and my M.Sc. of Biomedical Engineering from Louisiana Tech University. I worked on construction of electrochemical biosensors as my senior undergraduate project and polymeric/liposomal nanoparticles for drug delivery applications in my masters degree. After my masters, I moved to Koch Cancer Institute at MIT as formulation scientist and worked on synthesis of a chemotherapeutic oral film. My next position was a Research Associate in the Program in Molecular Medicine at UMass Medical School where I worked on synthesis and characterization of subunit vaccines based on Glucan Particle technology. I moved to the Mitchell lab to study the cell-cell variability in anticancer therapy while focusing on the dynamics of signaling networks in clonal cell populations.
Nicholas Vecchietti, Research Associate
I received both my B.Sc. and M.Sc. in Biology at the University of Insubria in Varese, Italy. My thesis project was conducted in Switzerland in collaboration with the Laboratory of Applied Microbiology lead by Dr. Mauro Tonolla at SUPSI University, where I investigated the eco-physiological interaction between anaerobic sulfur bacterial species. During that time, I gained experience in microbiology, microscopy and image analysis techniques. After my graduation, I joined UMass as Research Associate where I was optimizing techniques allowing live imaging of HIV-1 virus and collaborating in assembling a state of the art microscope for tracking viral particles during infection in cells. Currently in Mitchell’s lab I am investigating the response of yeast cells to stress conditions and I am participating in the studies on the evolution of antibiotic resistance in E.coli applying my expertise in microbiology and microscopy techniques.
Serkan Sayin, PhD student
I have received my B.Sc. in Molecular Biology and Genetics from the Izmir Institute of Technology where I performed research at Professor Ahmet Koc’s lab which studies aging and drug resistance using S. cerevisiae. I moved to Germany to pursue my M.Sc. degree in Life and Medical Sciences at the University of Bonn at the group of Prof. Dr. Joachim Schultze and Dr. Marc Beyer. Their research uses genomics approaches to solve complex immunology problems in macrophage and T-cell biology. There, I focused on genome engineering of macrophages by CRISPR/Cas9 to study long range DNA interactions. Currently, I am a graduate student at the University of Massachusetts Medical School. I have a diverse background in different fields of biological sciences, and now I would like to challenge myself in an interdisciplinary area of Systems Biology. I have recently joined the Mitchell lab to work on evolution of antibiotic resistance in E.coli and plasmid partitioning.
Tiffany Hua, Lab Engineer
I am a recent graduate of University of Massachusetts Amherst with a Bachelors degree in Mechanical Engineering. At UMass Amherst, I had the opportunity to work in Jungwoo Lee’s lab, which focuses on Translational Biomaterials & Tissue Engineering. In the Lee Group, I created dynamic bioreactor systems used to study Mechanobiology and the effects on mesenchymal stem cells. This undergraduate experience led me to UMass Medical School where I will continue to engineer customized systems for research. In the Mitchell Lab, I am interested in using programmable micro-controllers and electronic components to create controlled environments used to study cellular responses.
JACKSON COOLE, VISITING STUDENT
I am a current undergraduate at Mississippi State University pursuing a Bachelor degree in Biomedical Engineering. At Mississippi State I have had the opportunity to work in Dr. James Stewart’s lab studying the effects of environmental pollutants in the diabetic heart involving the AGE/RAGE signaling cascade and under Dr. Thomas Cathcart to computationally model that signaling cascade. I have been able to participate in summer research programs at the Baylor College of Medicine studying gene associations in the scientific literature and the University of Mississippi Medical Center studying the functional organization of the nucleus as well. My commitment to pursue graduate studies has led me to be a part of UMass Medical School’s Summer Undergraduate Research Program in the Mitchell Lab. I hope my summer’s work will allow me to gain new skillsets and provide valuable contributions to the Mitchell Lab’s work.