https://mitchell-lab.umassmed.edu/home daily 0.75 2024-06-03 https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1466050015303-TZW8AH4397Y6IJK9PLWQ/background-01.png Home https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1468376795888-MMPZPH17RRDUNTL3HZRU/background-01.png Home https://mitchell-lab.umassmed.edu/contact daily 0.75 2025-08-25 https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1468517459685-IV6FRW69CG28PUYOH7Y1/image-asset.jpeg Contact Our lab is located in the U. Mass medical school in the new Sherman center for Biomedical research. https://mitchell-lab.umassmed.edu/join daily 0.75 2019-07-24 https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1468514643055-3O647HQQDDVZQF87AQWL/image-asset.png Join https://mitchell-lab.umassmed.edu/research-old daily 0.75 2026-01-29 https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1623625659326-31553YZAHEDM5IDKNHYH/Model+systems.png Research (old) - Make it stand out Our lab uses model systems with varying levels of complexity to investigate the complex multi-lateral host-tumor-microbiome interactions https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1539620388534-7I0RAKLQBO6DSH5W9UUN/HostDrugBacteriaInteractions-03.png Research (old) Host-drug interactions are modulated by the host’s microbiome (via direct and indirect mechanisms). We are investigating these complex interactions in the specific context of the tumor-associated bacteria. https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1468428363279-LZWHINK2VG2NI3MKV8JY/Cell_Closeup.jpg Research (old) Host-targeted drugs can unintentionally hamper the integrity of the host’s microbiome by inhibiting the growth of some of its microbial members. This impact can, in turn, culminate in microbiome dysbiosis and can impact disease progression and treatment success. https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1468523275487-VE2VMX3OCEZLLX864KZ3/image-asset.png Research (old) Inhibition of cancer cell growth with targeted drug therapy is restricted due to rewiring of regulatory networks. A subpopulation of cells that have adapted to the drug within a two day treatment is marked by a green dye indicating that they are actively proliferating. https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1623626361833-L2NBY3DFP0SPWF853QQ6/Shared+goods.png Research (old) Microbial communities are often stabilized by cross-feeding interactions between different members of the community. Systematic mapping of all potent cross-feeding interactions between auxotroph E. coli strains revealed that some secreted metabolites are superior over other metabolites as shared goods. https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1623677255589-VAO1V5MMT0ZWI0N4NTJA/ColorfulMultiwell.jpg Research (old) We developed an automated platform for remote high-throughput experimentation. We used the platform to allow hundreds of high-school students to learn about evolutionary adaptation and the emergence of super-bugs (multi-drug resistant strains) https://mitchell-lab.umassmed.edu/people daily 0.75 2025-12-20 https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/231309e6-3d1a-45c0-9777-d9cf579452fd/IMG_3182.jpeg People - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1627356631500-691GEZUI9UUSF1QBD8F1/Amir+Mitchell+2018a_lowres.jpeg People Amir Mitchell. PI (amir.mitchell@umassmed.edu) https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1518301518553-6FYHX34U1W4DN2LT813M/BrittanyRosener.png People Brittany Rosener, postdoc (brittany.rosener@umassmed.edu) https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1594087004435-9CFGA4TBIQB7IHQJMGYC/MarianaNoto2020.jpg People Mariana Noto, PhD student (mariana.notoguillen@umassmed.edu) https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/b940e9c8-081c-4b61-9fae-87ac39d069c5/sydneyezekielengagement-130.jpg People - Make it stand out Sydney Schock, PhD student (sydney.schock@umassmed.edu) https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/352268b6-3910-46bd-b562-591233d99bb8/CarmenLee.jpg People - Make it stand out Carmen Li, PhD student (carmen.li4@umassmed.edu) https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/f4f75f33-6c34-4de1-80fa-7b3a77db548b/MichelleNarvaezRamos2023_low_res.jpg People - Make it stand out Michelle Narvaez Ramos, MD-PhD student (michelle.narvaezramos@umassmed.edu) https://mitchell-lab.umassmed.edu/publications daily 0.75 2026-02-19 https://mitchell-lab.umassmed.edu/news daily 0.75 2025-08-25 https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1746466144389-45DCAGRD128TPMKW1VR7/MattersMicrobial+podcast+2025.png News - Matters Microbial podcast Link to the Matters Microbial podcast, episode #89 on YouTube https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1665765131713-402B6K5QEMQA1D4HK3U2/Screen+Shot+2022-10-14+at+12.26.43.png News - Presentation on bacterial shared-goods Amir’s presentation from the Isaac Newton Institute conference on Microbial communities: current approaches and open challenges (UMCW06). Cambridge, UK, 2022 https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1627354743065-L7XUUP0X3S18MUOWO1AT/YoutubeClip2021b.jpg News - Our work in brief - The Tumor Microbiome https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1627354101434-GUZXP7G9O5NDL8QJFPRC/UMassNow_cover_2019.jpg News - Our Science Outreach with high-schools worldwide https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1627355370476-NT5E1HCWUWPR4RM2P4C0/MIRA+R35+UMassMed+Now.jpeg News - Mitchell Lab receives the NIGMS MIRA award https://mitchell-lab.umassmed.edu/evolution daily 0.75 2017-12-28 https://images.squarespace-cdn.com/content/v1/5761f5abbe6594a55dbc14c4/1486332001222-DX7SG3QUZYCE38HQ2UDF/ColorfulMultiwell.jpg Brief https://mitchell-lab.umassmed.edu/registration daily 0.75 2018-11-27 https://mitchell-lab.umassmed.edu/resources daily 0.75 2019-07-24 https://mitchell-lab.umassmed.edu/daily-feeds daily 0.75 2018-03-15 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